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Devnani points to the following culprits that can aggravate RLS: Over-the-counter antihistamines, cold, and allergy medications, including Benadryl, Tylenol PM, or NyQuil Antidepressants and selective serotonin-reuptake inhibitors (SSRIs), like fluoxetine and sertraline Antinausea drugs like Antivert, Phenergan, and Bonine Consult with your doctor before taking any medications to make sure they arent triggering symptoms, and stick to recommended dosing, Cline says