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Pen one runs your first phase

Consideraciones ticas Dado su carcter de revisin y la no participacin de pacientes o procedimientos, no aplica la necesidad del consentimiento informado

Both medications target incretin pathways, but their receptor activation profiles create distinct physiological effects

GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas