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Role of HIF-1 in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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In the context of MIRI, JAK2/STAT3 activation is often considered a protective response in the acute phase, promoting cardiomyocyte survival by upregulating anti-apoptotic proteins (like Bcl-xL and Mcl-1) and antioxidant enzymes (Liu P