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The clearance of ROS in the human body mainly depends on GSH, which is mainly composed of small molecular peptides composed of glutamate (Glu), cysteine (Cys), and glycine (Gly) (Xiao and Meierhofer, 2019)

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Initiation of GLP-1RA was defined as a new prescription of any GLP-1RA available in Italy (exenatide BID, exenatide OW, lixisenatide, liraglutide, dulaglutide, semaglutide OW, oral semaglutide) for patients who had never been treated with the same compound before, as evident from the diabetes treatment history recorded in the electronic chart