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"Based on our earlier findings on the effects of GlyNAC supplementation in other populations and the current finding that people hospitalized with COVID-19 had glutathione deficiency and increased oxidative stress, we considered whether GlyNAC supplementation could also combat these defects in COVID-19 and potentially be valuable in helping the body fight this serious infection

By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

Numerous mechanisms contribute to this action, including the reduction of ROS generation and the encouragement of Nrf2 nuclear translocation, which increases heme oxygenase-1 (HO-1) expression and lowers oxidative stress [175,176,177]