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It directly inhibits TGF-1/Smad signaling in HSCs, thereby reducing fibrosis and suppressing pro-inflammatory cytokines (TNF-, IL-6, IL-1) through the inhibition of the GPR120/NF-B pathway and modulation of the NLRP3 inflammasome

The commentary also notes that weight regain was not affected by whether patients took part in a lifestyle management program during treatment, though preliminary data suggest regain may be reduced when patients remain enrolled in such a program after stopping

Low sperm motility may be associated with oxidative stress, varicocele, smoking, heat exposure, inflammation, metabolic issues, and idiopathic male infertility

This reduction contributes to visible signs of aging, decreased energy, weakened immunity, and increased vulnerability to diseases