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What often surprises people is that the most disruptive symptoms are physical, not mental

10.3389/fphar.2020.00042 21 ChenY.LiuS.LiJ.LiZ.QuanJ.LiuX.et al (2020b)

For decades, we relied on the magic of glycemic control and control of hypertension to turn the tide of worsening DKD, only to see some patients with decent HbA1Cs still suffer from a decline of kidney function

A minimum 4-month rest period follows each cycle, with a maximum of 3 cycles per year