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The erectile response of the penis relies on maintaining equilibrium between vasoconstrictor agents, which induce contraction of cavernosal smooth muscle, thereby restricting blood flow, and vasodilator agents, which induce relaxation of cavernosal smooth muscle, thus facilitating increased blood flow and erection 26

Given the heterogeneity of NPCs, we further analyzed the scRNA-seq data (GSE165722) 26 from human NP tissues with mild (grades II and III) and severe (grades IV and V) degeneration to identify the potential pathogenic factors associated with IDD

He noted that the three pillars of an FDA finding of safe and effective include demonstrating clinical efficacy, validating the manufacturing process and completing the required toxicology studies