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The mechanism of action has been determined that KPV inhibits the activation of NF-kappaB and MAP kinase inflammatory signaling pathways, and reduces pro-inflammatory cytokine secretionacts via PepT1 expressed in immune and intestinal epithelial cells..[and] reduces the incidence of DSS- and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression (Dalmasso et al., 2008)

Multifunctional redox-responsive nanoplatform with dual activation of macrophages and T cells for antitumor immunotherapy

Further, a role in healthy aging is discussed and short-term, high-dose tocopherol vitamin E of up to 300 mg/day did not cause major side effects

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