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Second, many clinical trials are of relatively short duration (often 6 months), failing to capture the long-term efficacy and sustainability of interventions on OA progression, a inherently chronic disease

In Phase 2 trials published in the *New England Journal of Medicine* (2023), participants lost an average of 17.5% of body weight at the highest dose over 24 weeks outperforming tirzepatide and semaglutide in head-to-head data comparisons

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SAR QSAR Environ Res 32(1):2950 Cazarotto CJ et al (2018) Metaphylactic effect of minerals on immunological and antioxidant responses, weight gain and minimization of coccidiosis of newborn lambs