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36 Results from the Semaglutide and Walking Capacity in People with Symptomatic Peripheral Artery Disease and T2DM (STRIDE) trial also found that semaglutide 1.0 mg once weekly is associated with an increase in walking distance in individuals with symptomatic peripheral artery disease and T2DM

Given the relatively small size of SR18, the estimated binding free energy for SR18GLP-1R complex is noted to be 98.79 8.77 kcal/mol compared to 167.22 16.20 kcal/mol observed for GLP-1GLP-1R complex, which suggests that SR18 strongly binds to GLP-1R

JACC: Heart Fail 11(6):724726