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Consistent with decreased RNR activity, treatment of Control cells with nutlin-3 or MI-773 decreased levels of dAMP, a metabolite downstream of RNR (Fig 3E)

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Caspase-dependent protein degradation is also attenuated by IGF/PI3K/Akt signaling, whereas evidence for an effect on calpain-dependent protein degradation is inconclusive

FOXO4-DRI is supplied in lyophilized form strictly for controlled laboratory research applications