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GIP and GLP-1 are polypeptides that are degraded in vivo within minutes by hydrolysis of peptide bonds catalysed by the enzyme dipeptidyl-peptidase 4 (DPP-4

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The likelihood ratio based on the objective function value was used to test different hypotheses regarding the structure of the variancecovariance matrix for inter-individual variability and residual variability models, and to assess the covariate effects on toxicokinetic parameters