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Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure

14 Growth factors such as RPR (Recombinant Platelet-Derived Growth Factor), BMP-2 (Bone Morphogenetic Protein-2), FGF (Fibroblast Growth Factor), VEGF (Vascular Endothelial Growth Factor), TGF- (Transforming Growth Factor-beta), and BGF (Basic Growth Factor) play crucial roles in driving cellular processes by activating specific receptor-mediated signaling pathways that influence cellular proliferation, migration, differentiation, and survival

Despite the pharmacokinetic challenges posed by the low systemic bioavailability of key withanolides in human plasma, their substantial in vivo effectiveness seems to result from multiple interconnected mechanisms