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It also attenuates cardiac remodeling by reducing collagen deposition and cardiomyocyte apoptosis, while decreasing the expression of TGF-1 and phosphorylated-Smad3 [171]

This effect is partly attributed to weight loss, a known mechanism for lowering blood pressure, so it is not surprising that this is part of the mechanism for GLP-1 RAs blood pressure reduction [36, 37]