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Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial

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Modification Triggers: Persistent injection site reactions Significant sleep disruption Unusual fatigue or energy changes Any concerning physical symptoms Discontinuation Criteria: Severe allergic reactions Persistent adverse effects despite modifications Research objectives completed Subject withdrawal from study Rest Period Importance The rest period between active cycles represents a crucial component of effective epithalon dosage protocols