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While it is difficult to reconcile the differences between the studies in locus coeruleus neurons with those in HEK293 cells, one possible explanation may relate to the MOR-effector coupling studied in each cell type

Patients with pituitary adenomas also have increased DNA damage in peripheral blood lymphocytes due to the GH excess secretion ( IGF1 Promotes DNA Damage Repair of DNA DBSs IGF1 and IGF1R are necessary for nucleotide excision repair (Loesch et al., 2016)

The overlap interest is in supporting a more organized repair process rather than disorganized scar formation

Recent studies have shown that IFN- can downregulate SLC3A2 and SLC7A11 while upregulating ACSL4, promoting tumor cell ferroptosis