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The main pathophysiological mechanisms linking elevated UA with atherosclerosis and CVD are shown in Figure 2

Interestingly, this finding is also confirmed in fibroblast cells, postmortem AD brains examination at different Braak stages (Kumar et al., 2017

There are great variations in nuclear GSH concentration and its regulation mechanisms during the cell cycle since cells starting the proliferation phase have high levels of nuclear GSH, while resting cells have similar or lower GSH levels in the nucleus than in the cytoplasm (68, 72, 73)