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217 Similarly, PS2 overexpression increases p53 levels and activity to promote p53-dependent cell death, which indicates that APP and its proteolytic products play important roles in the regulation of p53 levels and activity

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The increased vascular permeability can be detected by measuring the extravasation of Evans blue dye

496 Conditional and neurone specific deletion of GDI1 (CamkII-Cre + -Gdi1 flox/Y model), showed that the down regulation of GDI in neurones in adult forebrain regions was sufficient to recapitulate the learning deficits previously shown in Gdi1 -null mice