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And for the obesity nutrition researchers in the world, why would anyone do something this extreme if they didn't have to

Impossible if you're changing three compounds simultaneously every two weeks

Nature 436 , 933938 (2005)

The following categories were used to classify the level of evidence in the included studies (27): (i) Persuasive: statistical significance per the random-effects model of p 1,000 cases, low heterogeneity among the selected studies ( I 2 1,000 cases, and most studies indicating a significant effect