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DSIP appears to enhance sleep architecture itself, potentially increasing deep sleep percentage regardless of circadian timing

In conjugation with the significant reduction in body weight, the weight of epididymal white adipose tissues was significantly reduced after treatment with 2.5 g/kg of KBP-089 and combinations of KBP-089 and liraglutide, whereas only the combination therapy significantly reduced the weights of inguinal and perirenal adipose tissue (Fig

Non-pharmacological strategies like optimised nutrition and physical activity remain foundational, but new drug classes including GLP-1RAs and SGLT2 inhibitors are expanding treatment options

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