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The injection should be aimed at the upper, outer quadrant of the buttock

Who Should Consider Alternatives to Semaglutide: Clinical Eligibility and Safety Framework Patients may benefit from exploring alternatives if they experience inadequate weight loss on semaglutide despite therapeutic dosing, develop intolerable GI side effects, or have contraindications (e.g., personal or family history of medullary thyroid carcinoma)

Gastrointest Endosc 2008;68:1008

The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior