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Pharmacological activation of hepatic TR potentiates the GLP-1 production Consistently, we found that pharmacological activation of hepatic TR by daily injection of MB07811, a liver-targeted TR-selective agonist, for five days could increase the plasma levels of GLP-1 and insulin, decrease the blood glucose levels, and as well as improve the oral glucose tolerance in MMI mice (Fig

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Microdosing, by contrast, typically involves taking less medication than prescribed or changing the dosing schedule, often outside standard treatment guidelines