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SIRT1 is often suggested to be a cytoprotective molecule in non-cancerous tissues exposed to chemotherapeutic injury ( Figure 10 , Table 6 )

Atherosclerosis, one of the main risk factors of CVD, consists of the initial endothelial cell injury followed by lipoprotein deposition, inflammatory reaction, and smooth muscle cell cap formation 2

Diabetologia 46 , 574578 (2003)