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DCA inhibits mitochondrial pyruvate dehydrogenase kinase that inactives the pyruvate dehydrogenase complex

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Published in 1974 and shared with other researchers, the new RIA helped to establish that many nutrients, in particular fats, stimulated the release of GIP in the intestine but that fats only activated insulin 'when blood sugar levels were artificially raised as would be expected of a true incretin' (Marks 2020