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Less Common but Serious Side Effects: Hypoglycemia (Low Blood Sugar) : Especially when used with other diabetes medications like insulin or sulfonylureas

Ethical concerns also arise when prescribing chronic pharmacotherapy to a developing population, underscoring the importance of cautious, individualized use

Under normal conditions, Nrf2 is degraded through its interaction with Kelch-like ECH-associated protein 1 (Keap1), whereas under oxidative stress conditions, Keap1 is oxidized and Nrf2 is translocated to the nucleus, where it induces the expression of several genes 19

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