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Gastrointestinal symptoms like nausea and vomiting are the primary reported effects

Despite this, no increase in heart attacks or serious heart problems has been reported so far

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They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies