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A nutrient can be useful when it corrects the right deficiency and counterproductive when it pushes a vulnerable pathway in the wrong direction

Comparative analysis of the correlation coefficients revealed that negative correlations between ACC Gln levels and Sensory Sensitivity, between rTPJ Gln levels and Sensation Avoiding, and between the Gln/Glu ratio and Sensory Sensitivity were unique to the ASD group: lower values in these neurometabolite measures were associated with increases in the severity of these sensory sensitivity-related symptoms in ASD

A separate 2025 narrative review confirmed three total published human pilot studies and noted that no major adverse events were reported across those pilots [15]

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