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Some embodiments provide medicaments, supplements, nutraceuticals, functional foods (e.g., any fresh or processed food that claims health promoting and/or disease preventing properties that exceed the basic nutritional functions of providing nutrients), pharmaceuticals, Over The Counter (OTC) products, oral care products, cosmetics such as sweet lipstick, and other personal care products, including one or more of compounds 101-105 or cooling compositions described herein

In controlled human dermal studies, 12-week topical application improved measurable collagen density in 70% of subjects

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