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In an open-label design, patients were randomly assigned to radiation therapy alone, 3 months of neoadjuvant androgen deprivation therapy (NADT) (goserelin 3.6 mg subcutaneously each month plus flutamide 250 mg PO tid) for 2 months before and during radiation, or 6 months of NADT for 5 months before and during radiation.[14][Level of evidence A1] After a median follow-up of 10.6 years, there were no statistically significant differences between the radiation-alone group and the radiation plus 3 months of NADT group

This Matrixyl 3000 and Argireline article is useful if you want to compare it with expression-line peptides that can also contribute to smoother-looking skin

In fact, experimental studies have documented that effective sclerosing solutions do not have to produce tissue necrosis on intradermal injection (see Chapter 8)

7 As a result, carriers are thoughtfully evaluating the efficacy and use cases of these new drugs to determine how they should be covered, based on the latest clinical studies and medical evidence