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Punctured vials during travel: Vials in active multi-dose use require the same storage discipline during travel as at home: temperature control, light protection, and aseptic technique on every draw

It can be administered by IM or IV routes, thus it becomes a preferred choice in numerous clinics and hospitals

intramuscular route: count injections given Visit 4 (week 52) Anamnesis: record lifestyle habits and use of alcohol Symptoms: record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Questionnaires: EuroQoL-5D, satisfaction and preferences Assessment of haemogram and serum vitamin B12 concentration Assessment of adverse effects Assess adherence to treatment: oral route count number of vials used

Endotoxin testing