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Description

Removing vials from storage, leaving them at room temperature, and returning them repeatedly to the freezer can cause freeze thaw stress, which significantly compromises the peptides integrity

The two incretin peptides that enable this effect are the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide 1 (GLP-1), which have cognate receptors (GIPR and GLP-1R) on islet -cells as well as in other tissues