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For the mediation analysis on the histology endpoints evaluating change in body weight as mediator, data were based on complete-case on-treatment measurements to evaluate the mechanistic action of semaglutide in MASH (hence, data outside the on-treatment observation period were excluded)

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics

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The results showed that the use of the incretin-based therapy could be associated with ameliorations in the depressive symptoms of newly diagnosed T2DM patients