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Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016
Physiol Rev 89:13791412 [DOI] [PMC free article] [PubMed] [Google Scholar] Levitt ES, Clark MJ, Jenkins PM, Martens JR, Traynor JR
People with already decent sleep may experience subtler effects
Epub ahead of print
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