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Hypoxia results in the secretion of hypoxia inducible factor (HIF)-1 by local adipocytes, which stimulates hypoxia response elements on a number of genes including the vascular endothelial growth factor (VEGF) gene and inducing proliferation of stem cells in the adipose tissue (50)

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These findings underscore the unique pathological timeline and molecular changes in the TgAPParc model, providing a valuable tool for studying Alzheimers disease pathogenesis and therapeutic development

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