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However, when the cell detects an apoptotic stimulus, such as DNA damage or metabolic stress, the intrinsic apoptotic pathway is triggered and mitochondrial cytochrome c is released into the cytosol (Kroemer et al., 2007)
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Currently, PPI drugs that have been approved for clinical use are mainly divided into small-molecule drugs and biologics (including proteins and antibodies), for example, navitoclax and its analogs that prevent the interaction between B-cell lymphoma-2 (BCL-2) and proapoptotic proteins BCL-2 homologs antagonist/killer (BAK) and BCL-2-associated X-protein (BAX) [5] and the antibody trastuzumab that are used to block the human epidermal growth factor receptor-2 (HER2) receptor [6]
Mazura AD, Ohler A, Storck SE, Kurtyka M, Scharfenberg F, Weggen S, et al
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