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In a Lilly-funded trial published by The Lancet, patients with type 2 diabetes who took 12 to 36 milligrams of orforglipron lost an average of 15 to 20 pounds, compared with 8 to 11 pounds for those taking 7 to 14 milligrams of Rybelsus

Li, X., Wang, X., Huang, B

Keywords: Heart failure with reduced ejection fraction (HFrEF), GLP-1 receptor agonists (GLP-1 RAs), Type 2 diabetes mellitus (T2DM), Cardiovascular outcomes, Dipeptidyl peptidase-4 inhibitors (DPP4i) 1

Since then its been studied extensively for its effects on gene expression influencing thousands of genes related to collagen production, tissue remodeling, antioxidant protection, and inflammation control