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Unlike existing injectable PCSK9 inhibitors, which face challenges with cost and patient adherence, enlicitide is a once-daily pill taken on an empty stomach, potentially improving accessibility and compliance
Pancreatic Function: Stimulating the beta cells of the pancreas to release insulin in a glucose-dependent manner, ensuring blood sugar remains stable after a meal
Glucagon acts in the liver via cAMP (Halden et al., 2016)
In summary, GLP-1R on -cells is activated and promotes growth inhibitory hormone secretion, creating a multilayered inhibitory mechanism that effectively reduces glucagon secretion, and in turn lowers blood glucose levels
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