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However, our results highlighted also an up-regulation of estrogen signaling as well as an impairment of extracellular matrix organization and sirtuin signaling pathway

ROS encompass both free oxygen radicals and non-radical species, including major molecules, such as superoxide anion radical (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical ( OH), and nitric oxide ( NO), with the latter being classified as a reactive nitrogen species [12]

Furthermore, these interactions between these proteins and A, p-tau, and other related factors ultimately influence neuronal function and lead to cognitive deficits, as observed in AD

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