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That said, habitual temperature excursions compound over time

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Oxidative stress results from an imbalance between free radicals and antioxidants in the body, leading to cellular damage and inflammation

Some GPxs are therefore dependent on Se and use GSH as a reducing agent, while others, called TGPx, do not contain Se (NS-GPx) and reduce ROS using thioredoxin, which acts as ROS sensors in various pathways and signal transduction