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277 The estimated number of people age 65 and older with clinical Alzheimer's dementia comes from an updated study using the Chicago Health and Aging Project (CHAP), a populationbased study of chronic health conditions of older people, and the latest data from the 2024 population projections from the U.S

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doi:10.7759/cureus.31425

Off-Target Considerations The protein fibroblast activation protein-alpha (FAP, Aertgeerts etal., 2005) is the closest relative of DPP-4 (~50% sequence similarity)