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Contraindications include: Active seizure disorder or history of seizures Anorexia nervosa or bulimia nervosa (current or past) Abrupt alcohol withdrawal or sedative withdrawal Concurrent use of MAOIs These contraindications apply regardless of whether GLP-1 is being used

The higher food volume creates a more favorable pH environment in the stomach and provides more substrate for the bacteria to work with once they reach the lower gut

For those who are also exploring other peptides that require reconstitution, the techniques and principles covered here transfer directly to other compounds

Muri et al., 2024