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doi: 10.1016/j.neuroimage.2010.01.081, 141 SticeE.YokumS.BurgerK

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Modern Prescription Weight Loss Options Modern prescription weight loss options focus on changing how the brain and body regulate hunger, cravings, and energy use

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SURMOUNT-1 showed a mean 21% body weight loss (~48 lbs) with the 15mg dose over 72 weeks

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Significant targets and the effects of PKGI in SMC are activation of myosin light chain phosphatase, inhibition of PLC, inhibition of the IP 3 receptor, inhibition of plasma membrane localized L-type Ca 2+ channels, and activation of plasma membrane localized calcium-activated K + channels (commonly called the big potassium, BK, channels)

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