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If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature)

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Instead, they may be more effective as part of multimodal strategy that includes glycemic control, anti-inflammatory interventions, early enteral nutrition, and rehabilitation efforts aimed at preserving muscle mass and function in critically ill patients (59)