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Trial findings are collected under structured conditions, with defined inclusion criteria, monitoring procedures and safety reporting systems

In absolute terms, the 12 mg dose translated to an average loss of approximately 70 pounds (32 kg) at 80 weeks of treatment

Patients new to GLP-1s typically start with semaglutide or tirzepatide

The most commonly reported side effects of GLP-1 receptor agonists, documented across multiple large randomized controlled clinical trials enrolling thousands of participants, are gastrointestinal: nausea, vomiting, diarrhea, constipation, and abdominal discomfort, all of which are most commonly reported during the initial titration phase when dosage is being escalated from a low starting point toward a therapeutic target and the body is still adapting to the mechanism of action