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2) The findings of the study performed by Cui et al provided evidence that topical application of glutathione amino acid precursors effectively enhances cellular glutathione (GSH) levels and protects the skin from oxidative and environmental stressors

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More recently, the A946T variant alone was confirmed to lead to increased basal type I IFN activity in reporter cell lines due to increased MDA5 ATPase activity, which may enhance filament formation on dsRNA and downstream signaling (115)