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Both recycling and transcytosis rely on strict pH dependent Fc binding to FcRn, with binding at acidic (pH 6.55.5) and release or no binding at neutral pH 21,22
For everything else, injection is the clinically validated route
3.1.2 Safety In total, 21 TEAEs were reported in 11 participants: 14 events were reported in eight participants (57.1%) with normal renal function, two in one participant (14.3%) with mild renal impairment, and five in two participants (28.6%) with moderate renal impairment (Table 3)
Anyone promising results in 4 weeks is overstating the biology
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