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This crucial dual action of reducing synthesis and increasing catabolism effectively decreases intrahepatic triglyceride content

[Google Scholar] [50].Lee TS, Park EJ, Choi M, Oh HS, An Y, Kim T, Kim TH, Shin BS, Shin S, Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats, Journal of Chromatography B 1221 (2023) 123688

This was used either as a fixed dose (staying at 4mg throughout) or as a faster escalation route to 8mg

5 Randomized data suggest that intermittent energy restriction achieves similar HbA1c reductions to continuous energy restriction, with no clear between-group differences in GLP-1 concentrations, so any specific GLP-1 benefit of IF remains uncertain