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These effects are mediated by: Improved endothelial function and nitric oxide bioavailability Reduced vascular inflammation and oxidative stress Stabilization of atherosclerotic plaque Enhanced cardiac metabolism and mitochondrial efficiency From a longevity standpoint, microdosing may maintain low-grade GLP-1 receptor activation within vascular tissue, supporting arterial flexibility, autonomic tone, and lipid regulation without the gastrointestinal intolerance often limiting high-dose use

GLP-1 and GIP receptor activation produces gastrointestinal effects (nausea, reduced appetite) that are dose-dependent

However, injectable semaglutide (which PlexusDx provides through licensed 503A compounding pharmacies) works systemically and does not chemically bind to warfarin, apixaban, rivaroxaban, or dabigatran

[1] This incretin hormone plays a crucial role in regulating blood glucose levels, appetite, and overall metabolic health