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Next-generation combinations (GLP-1 + GIP, triple agonists with glucagon, GLP-1 + amylin) are even more powerful and represent the future of metabolic therapeutics - potentially 25-30% body weight reduction with profound improvements in liver fat, insulin sensitivity, and cardiovascular markers

Hypoglycaemia risk increases significantly when Ozempic is combined with sulphonylureas or insulin therapy, requiring dose adjustment of these medications

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